Chronic Intestinal Pseudo-Obstruction (CIP)
Chronic intestinal pseudo-obstruction (CIP) is a disorder of the gastrointestinal (GI) tract characterized by symptoms and signs (present for at least 6 months) that suggest mechanical obstruction of the intestinal tract.
Although the clinical findings of CIP are usually indistinguishable from mechanical obstruction, the etiology, pathology, and treatment are quite different. The heterogeneous nature of this condition, reflected by the multiple and diverse etiologies described below, has precluded the adoption of a consensus statement on the classification and treatment of this disorder. To date, most research has focused on identifying and characterizing the underlying etiologies of CIP.
The myriad of causes, including collagen vascular diseases, paraneoplastic syndromes, and primary motor and neurologic disorders, have, in general, forced clinicians to focus therapy on symptom relief, rather than treatment of the underlying disorder.
We will focus on the following five aspects of CIP:
(1) understanding the impact of CIP,
(2)the causes and mechanisms of CIP,
(3) clinical presentation,
(4) making the diagnosis, and
(5) treatment.
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